One of the most exciting applications of Big Data in biology is to fuel innovation in drug discovery and development, and ultimately enable precision medicine. Having a deeper understanding of how genetic, environmental and lifestyle influence risk for disease, both on an individual and population-wide level, will be critical. Precision medicine anchored on deep understanding of human genetics and facilitated by Big Data, affords the potential to identify and validate novel therapeutic targets for a wide ranges of indications, from Mendelian to chronic diseases. For example, humans with ‘extreme phenotypes’ can shed light on the underlying disease and drug targets that could potentially be applied to a broader population. While there are some significant challenges that need to be overcome, include logistics (efficiently processing a vast array of disparate data) and validation, the opportunities for innovation on the drug discovery and development side are vast. In this Session, the speakers will address their efforts to meet this challenge.

Session ID: 24465